Kandouz M. (Ed.) Intercellular Communication in Cancer

Dordrecht: Springer Netherlands, 2015. — 366 p. — ISBN: 978-94-017-7379-9, 978-94-017-7380-5.Contributions from leading scientists in the field will ensure access to the most reliable and up to date research and concepts (Novelty and reliability)
Basic and translational aspects will attract basic scientists and clinicians alike
Comprehensive color illustrations which will be helpful to scholars and studentsCells are by nature compelled to live in groups. They develop dependence over signaling cues received from their microenvironment, in particular from other cells, whether of their own “kind” or of a different type. Therefore, communicating with these cells is a critical aspect of their behavior and fate, as they live and die normally or as they undergo disease-related pathological changes, with dramatic repercussions.
In this book, we have asked expert researchers in the field of Intercellular Communication in Cancer to provide chapters on different aspects of interaction between neighboring cells, in the context of cancer diseases. We have specifically focused our efforts on membrane-to-membrane contact-based rather than growth factors-mediated modes of intercellular communications.
The contributing authors provide an extensive overview of their respective area of specialization, with an in-depth discussion of the molecular mechanisms of cell-cell interactions, the impact on tumor progression and response to therapies, as well as the cancer diagnostic value of this scientific information.
This book aims to introduce essential aspects of the normal and pathological cellular fate and homeostasis to both scientists and clinicians, and also to provide established researchers with an update on the novelties and future directions this expanding field is witnessing.Beyond the Channel: Role of Connexins in Regulating Normal and Cancerous Processes in the Mammary Gland
Connexins: Bridging the Gap Between Cancer Cell Communication in Glioblastoma
MicroRNA and Gap Junctions in Glioblastoma Cells: Implications for Cellular Therapy
Dynamic Regulation of Adherens Junctions: Implication in Cell Differentiation and Tumor Development
Cadherin-Based Cell-Cell Adhesions: Adhesion Structure, Signalling and Computational Modeling
E-Cadherin/Catenin Complex Modulations in Human Oral Cancer
Tumor-Derived Exosomes in Metastasis Signaling and Implications
Tunneling Nanotubes: Intercellular Conduits for Direct Cell-to-Cell Communication in Cancer
Cell-Cell Fusion, Chemotaxis and Metastasis
Role of the Family of Ephs and Ephrins in Cell-Cell Communication in Cancer
Computational Approaches to Modeling of Molecular Interactions in Multicellular Systems
Contact Normalization or Escape from the Matrix
Intercellular Communication, the Tumor Microenvironment, and Tumor Progression