Bonavida B. (Ed.) Nitric Oxide and Cancer: Pathogenesis and Therapy

Cham, Switzerland: Springer International Publishing, 2015. — 308 p. — ISBN: 978-3-319-13610-3, 978-3-319-13611-0.Nitric Oxide and Cancer: Pathogenesis and Therapy provides the latest research and applications of nitric oxide (NO) in cancer written by experts in the field. The volume reviews significant advances in the biochemical and molecular biology of NO-mediated effects in cancer. Additionally, it explores NO and its relationship to cancer, delineating its roles in the pathogenesis, prognosis, gene and protein modifications, regulation of resistance to cytotoxic drugs and immunotherapies, and potential therapeutic applications. Nitric Oxide and Cancer addresses the burgeoning interest in a rapidly advancing field, and serves as both a valuable resource for scientists, clinicians, students, and health professionals and a reference for teaching and educational purposes.Inflammation-Associated Carcinogenesis Involves Interaction Between the iNOS/NO and Wnt/β-catenin Signaling Pathways
Nitric Oxide and Genomic Stability
Targeting Hyponitroxia in Cancer Therapy
Mechanisms of Nitric Oxide-Dependent Regulation of Tumor Invasion and Metastasis
Role of Nitric Oxide in the Regulation of the Pro-tumourigenic Hypoxic Phenotype: From Instigation to Mitigation
S-Nitrosylation and Cancer
Impacts of S-Nitrosylation in Cancer
S-Nitrosylation in Cancer Cells: To Prevent or to Cause?
The Emerging Role of Protein S-Nitrosylation in Cancer Metastasis
Modulation of Anti-tumor Immune Responses by NO
Nitric Oxide, Immunity and Cancer: From Pathogenesis to Therapy
Regulation of Anti-Tumor Immune Responses
Nitric Oxide: Immune Modulation of Tumor Growth
Therapeutics and Overcoming Resistance
Pivotal Role of Nitric Oxide in Chemo and Immuno Sensitization of Resistant Tumor Cells to Apoptosis
Emerging Role of NO-Mediated Therapeutics
Photodynamic Therapy and Nitric Oxide
Regulation of Cell Death Signaling by Nitric Oxide in Cancer Cells
Discovery and Development of RRx-001, a Novel Nitric Oxide and ROS Mediated Epigenetic Modulator
NO Meditated Alterations in Gene Products
Nitric Oxide, Coagulation and Cancer
Neutral Sphingomyelinase 2: Structure, Function, and Regulation with Emphasis on Nitric Oxide Involvement and Potential Implications for Cancer Therapy