Robert J. Textbook of Cell Signalling in Cancer: An Educational Approach

Cham, Switzerland: Springer International Publishing, 2015. — 328 p. — ISBN: 978-3-319-14339-2, 978-3-319-14340-8This book provides a simplified, yet comprehensive, overview of the signalling pathways operating between and inside cells, which will help younger oncologists find their way in the labyrinth of signalling pathways and in the multitude of signals and signal receptors, transducers and effectors that contribute to oncogenesis.This comprehensive reference text is based on the master’s courses delivered by Prof. Jacques Robert to graduate students at the University of Bordeaux, France. It includes a large number of colour schemas and figures that have been improved year after year for educational purposes. Signalling pathways are described individually and in depth, but without ignoring the multiplicity of interconnections and crosstalk. The presentation of each pathway is followed by a brief description of the alterations found in cancers as well as of the targeted pharmacological approaches that can be used to prevent or overcome the consequences of these oncogenic alterations. The basic mechanisms of molecular biology at the DNA replication, RNA transcription and protein activity levels are presented in a series of didactic annexes, enabling readers to better understand the alterations in signalling pathways.Growth Factors and Tyrosine Kinase Receptors
MAP Kinase Pathway
Phosphatidylinositol 3-Kinase Pathway
Cytokines Pathway
TGFβ Pathway
G-Protein-Coupled Receptors
Wnt Pathway
Notch Pathway
Hedgehog Pathway
Integrins
Semaphorins and Adhesion Molecules
Toll-Like Receptors, Interleukin 1 and NFκB
Lymphocyte Receptor Pathways
Nuclear Receptor Pathways
Ion Channel-Coupled Receptors
Signalling by Oxygen and Nitric Oxide
Cell Cycle Control
Apoptosis Induction and Regulation