Dietel M., Wittekind Ch., Bussolati G., von Winterfeld M. (Eds.) Pre-Analytics of Pathological Specimens in Oncology

Springer International Publishing, 2015. — 133 p. — (Recent Results in Cancer Research 199). — ISBN: 978-3-319-13956-2, 978-3-319-13957-9.Offers guidance in how to optimize the pre-analytical handling of tissue and improve diagnostic quality
Discusses the importance of cold ischemia time
Examines the value of vacuum-based preservation and two-temperature fixationThis book presents an overview of the most important current developments in the pre-analytical handling of tissue. It addresses in particular potential ways to improve the situation whereby methods employed in the pre-analytical phase – the period from surgical removal of tissue to the start of pathological processing – have remained essentially unchanged for decades with only modest standardization. It is examined how the pre-analytical period can be optimized, resulting not only in an increase in diagnostic quality but also in a reduction in processing time and costs. Among the key topics examined are the so-called cold ischemia time between tissue removal and fixation, the potential superiority of vacuum-based preservation over immediate formalin fixation, two-temperature fixation, molecular analysis methods, and the pre-analytics of specimens from particular tissues. Readers will find this book to be an important update that reveals the full importance of the pre-analytical phase for quality of pathological work-up.The Pre-analytical Phase in Surgical Pathology
Histologic Validation of Vacuum Sealed, Formalin-Free Tissue Preservation, and Transport System
The Evolution of Pre-analytic Factors in Anatomic Pathology
Tissue Heterogeneity as a Pre-analytical Source of Variability
Standardized Processing of Native Tissue in Breast Pathology
Short Formalin Fixation and Rapid Microwave Processing Do Not Affect HER2 Testing
Current Projects in Pre-analytics: Where to Go?
Preanalytics in Lung Cancer
RNA Quality in Fresh-Frozen Gastrointestinal Tumor Specimens — Experiences from the Tumor and Healthy Tissue Bank TU Dresden
Bone Marrow Work-up: Report of a Pilot Study
Two-Temperature Formalin Fixation Preserves Activation States Efficiently
Towards the Lean lab: The Industry Challenge