Rapozzi V., Jori G. (Eds.) Resistance to Photodynamic Therapy in Cancer

Springer International Publishing, 2015. — 248 p. — (Resistance to Targeted Anti-Cancer Therapeutics 5). — ISBN: 978-3-319-12729-3, 978-3-319-12730-9.Explores mechanisms of action in PDT, the relationship between PDT cytotoxicity and cellular changes
Discusses the development of new technological advances in PDT for cancer
Offers strategic approaches to reduce multi-drug resistance of tumor cells by PDTThis volume provides a comprehensive review of resistance induced by photodynamic therapy (PDT) in tumor cells. Understanding the underlying mechanisms in this process leads to the improvement of therapeutic modality, in combination with chemotherapy, immunotherapy, and radiotherapy. Photodynamic therapy is a minimally invasive therapeutic procedure that can exert a selective or preferential cytotoxic activity toward malignant cells. The procedure involves administration of an intrinsically non-toxic photosensitizing agent (PS) followed by irradiation at a wavelength corresponding to a visible absorption band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Studies reveal that PDT can be curative, particularly in early stage tumors and this volume explores the potential of PDT, but also reveals strategic approaches to overcome resistance in tumor cells.Basic and Clinical Aspects of Photodynamic Therapy
Mechanisms of Resistance to Photodynamic Therapy: An Update
Tumor Microenvironment as a Determinant of Photodynamic Therapy Resistance
Autophagy Induced by Photodynamic Therapy (PDT): Shaping Resistance Against Cell Death and Anti-Tumor Immunity
Isolation and Initial Characterization of Resistant Cells to Photodynamic Therapy
GRP78-targeting Sensitizes Cancer Cells to Cytotoxic Effects of Photodynamic Therapy
Optimization of Photodynamic Therapy Response by Survivin Gene
Cellular Targets and Molecular Responses Associated with Photodynamic Therapy
How Nanoparticles Can Solve Resistance and Limitation in PDT Efficiency
Mechanisms of Tumor Cell Resistance to ALA-PDT
Melanoma Resistance to Photodynamic Therapy