Kaneez F. (ed.) Patch Clamp Technique

Rijeka: InTech, 2012. - 368 p.This book deals with the understanding of endogenous mechanisms of cells and their receptors as well as advantages of using this technique. It covers the basic principles and preparation types and also deals with the latest developments in the traditional patch clamp technique. Some chapters in this book take the technique to a next level of modulation and novel approach.
The patch-clamp technique was developed by Neher and Sakmann in 1976 as an effective refinement of the voltage-clamp-assay that demonstrated the function of single ion channels in fundamental cellular process. The patch-clamp technique has revolutionized the study of ion channels in a wide variety of cells.