Clarke W., Dasgupta A. Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions, and Pharmacogenomics

Elsevier, 2016. — 371 p. — ISBN: 978-0-12-802025-8Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics focuses on critical issues in therapeutic drug monitoring including special requirements of therapeutic drug monitoring important to special populations (infants and children, pregnant women, elderly patients, and obese patients). The book also covers issues of free drug monitoring and common interferences in using immunoassays for therapeutic drug monitoring.
This book is essential reading for any clinician, fellow, or trainee who wants to gain greater insight into the process of therapeutic drug monitoring for individual dosage adjustment and avoiding drug toxicity for certain drugs within a narrow therapeutic window. The book is written specifically for busy clinicians, fellows, and trainees who order therapeutic drug monitoring and need to get more familiar with testing methodologies, issues of interferences, and interpretation of results in certain patient populations.Overview of Therapeutic Drug Monitoring
Immunoassays and Issues with Interference in Therapeutic Drug Monitoring
Application of Chromatography Combined with Mass Spectrometry in Therapeutic Drug Monitoring
Clinical Utility of Free Drug Monitoring
Therapeutic Drug Monitoring of Newer Antiepileptic Drugs
Therapeutic Drug Monitoring of Antiretrovirals
Therapeutic Drug Monitoring in Infants and Children
Therapeutic Drug Monitoring in Pregnancy
Therapeutic Drug Monitoring in the Elderly
Therapeutic Drug Monitoring in Obese Patients
Special Issues in Therapeutic Drug Monitoring in Patients with Uremia, Liver Disease, and Critically Ill Patients
Integrating Therapuetic Drug Monitoring and Pharmacogenomics
Warfarin Pharmacogenomics
Drug Monitoring in Alternative Matrices
Integrating and Supporting Therapeutic Drug Monitoring in a Hospital System