Langenau D.M. (Ed.) Cancer and Zebrafish: Mechanisms, Techniques, and Models

Springer International Publishing, 2016. — 552 p. — (Advances in Experimental Medicine and Biology 916). — ISBN: 978-3-319-30652-0, 978-3-319-30654-4.Provides the most up-to-date research on zebrafish models for oncogene and tumor suppressor discovery
Explores potential drug targets in various cancers, including leukemia, melanoma, pancreatic and liver cancers
Reviews allograft cell transplantation and xenograft transplantation in zebrafishThis volume focuses on defining the unique attributes of using the zebrafish cancer model for discovering important pathways and potential drug targets for the treatment of human cancers. Using the zebrafish model, the volume explores oncogene and tumor suppressor discovery, chemical genetic approaches, genomics, epigenetics, cancer imaging, and cell transplantation. Contributed chapters come from the most prominent laboratories working in this field, which provides a unique perspective on zebrafish models from a wide spectrum of the research community. In addition, the book offers a detailed analysis of the most current research in the area for specific zebrafish cancer models, including T cell leukemia, rhabdomyosarcoma, liver and pancreatic cancer, melanoma, neuroblastoma, germ cell tumors, and malignant peripheral sheath tumors. A chapter is also dedicated to the development and utilization of other piscine models of cancer. The compilation of chapters in the volume culminates into a comprehensive and definitive text on zebrafish and cancer, providing a much needed resource on the powerful attributes of the zebrafish model system.Uncharted Waters: Zebrafish Cancer Models Navigate a Course for Oncogene Discovery
The Toolbox for Conditional Zebrafish Cancer Models
Approaches to Inactivate Genes in Zebrafish
Tumor Suppressors in Zebrafish: From TP53 to PTEN and Beyond
Identifying Novel Cancer Therapies Using Chemical Genetics and Zebrafish
Genomic Approaches to Zebrafish Cancer
Transcriptomic Analyses in Zebrafish Cancer Models for Global Gene Expression and Pathway Discovery
Zebrafish Discoveries in Cancer Epigenetics
Lymphatics, Cancer and Zebrafish
In Vivo Imaging of Cancer in Zebrafish
Imaging Cancer Angiogenesis and Metastasis in a Zebrafish Embryo Model
Allograft Cancer Cell Transplantation in Zebrafish
The Zebrafish Xenograft Platform: Evolution of a Novel Cancer Model and Preclinical Screening Tool
Automation of Technology for Cancer Research
Zebrafish Models of Human Leukemia: Technological Advances and Mechanistic Insights
Zebrafish Rhabdomyosarcoma
Baiting for Cancer: Using the Zebrafish as a Model in Liver and Pancreatic Cancer
Focusing the Spotlight on the Zebrafish Intestine to Illuminate Mechanisms of Colorectal Cancer
Zebrafish Melanoma
Neuroblastoma and Its Zebrafish Model
Zebrafish Germ Cell Tumors
Malignant Peripheral Nerve Sheath Tumors
Xiphophorus and Medaka Cancer Models