Isaacs J., Whitesell L. (Eds.) Hsp90 in Cancer: Beyond the Usual Suspects

Academic Press, 2016. — 288 p. — (Advances in Cancer Research Volume 129). — ISBN: 0128022906, 978-0-12-802290-0, 9780128024836, 0128024836.Focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins
Highlights the rapidly evolving understanding of the fundamental roles of Hsp90 in cancer biology
Discusses the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progressionDescriptionHsp90 in Cancer: Beyond the Usual Suspects, the latest volume in the Advances in Cancer Research series, focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins and discusses some of the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression.The information in this volume will be of interest to a broad range of basic and translational scientists, not only in the relatively narrow field of protein folding/biochemistry, but in other areas of cancer biology and clinical oncology.Unusual Suspects in the Twilight Zone between the Hsp90 Interactome and Carcinogenesis
Impact of Post-translational Modifications on the Anticancer Activity of Hsp90 Inhibitors
Anticancer Inhibitors of Hsp90 Function: Beyond the Usual Suspects
HSP90 in Cancer: Transcriptional Roles in the Nucleus
Hsp90 as a ‘Chaperone’ of the Epigenome: Insights and Opportunities for Cancer Therapy
Emerging Roles of Extracellular Hsp90 in Cancer
GRP94/gp96 in Cancer: Biology, Structure, Immunology and Drug Development
HSP90 and Immune Modulation in Cancer
Hsp90: A Global Regulator of the Genotype-To-Phenotype Map in Cancers