Pirtoli L., Gravina G.L., Giordano A. (Eds.) Radiobiology of Glioblastoma: Recent Advances and Related Pathobiology

Humana Press, Switzerland, 2016, 305 p., ISBN: 978-3-319-28303-6, 978-3-319-28305-0This text properly considers the most recent and relevant advances in molecular RB of GB, taking into account the related topics of pathobiology, and underscores the most promising translational perspectives from the preclinical to the clinical domain. Section I (From Bedside to Bench) discusses conditions associated with RT resistance of GB and the consequent RB hints, technology improvements intended to overcome RT-resistance of GB, mathematical modeling of RB parameters from clinical studies, the present impact of molecular prognostic factors in therapy of GB, and RT tolerance of normal brain. Section II (Preclinical Research and Pathobiology Topics) presents the traditional and mechanistic/molecular approaches to RB of GB, genetic and epigenetic studies on GB, issues of cell-death pathways, stem-like cells, invasiveness, tumor microenvironment, hypoxia, mi-RNA manipulations, and nanoparticle technology. Section III (Translational Perspectives) presents RB issues related to molecular profiling and classification of GB as frames of reference for clinical studies, translational perspectives of gene therapy, evolving protocols based on pre-clinical data and large data-bases and ontologic models.Radiobiology of Glioblastoma: Recent Advances and Related Pathobiology will be of great value to pathologists, medical oncologists, radiation oncologists as well as basic researchers and clinical investigators.Introduction and Background
The “Radioresistance” of Glioblastoma in the Clinical Setting, and the Present Therapeutic Options
Radiobiological Hints from Clinical Studies
Chemoradiotherapy: Radiation Total Dose and Fractionation
Clinical Evidence and Radiobiological Background of Particle Radiation Therapy
Mathematical Modeling of Radiobiological Parameters
Clinical, Pathological, and Molecular Prognostic Parameters in Glioblastoma Patients Undergoing Chemo- and Radiotherapy
Radiation Tolerance of Normal Brain: QUANTEC 2010 and Beyond
Basic Knowledge of Glioblastoma Radiobiology
The Immune System and Its Contribution to the Radiotherapeutic Response of Glioblastoma
Genetic and Epigenetic Determinants in Tumor Initiation and Progression of Glioblastoma
Tumor Microenvironment, Hypoxia, and Stem Cell-Related Radiation Resistance
Cell Death Pathways, with Special Regard to Ionizing Radiation and Temozolomide
miRNA Manipulation in Modifying Radiation Sensitivity in Glioblastoma Models
NanoMaterials Technology for Research Radiobiology
Preclinical Models of Glioblastoma in Radiobiology: Evolving Protocols and Research Methods
From Molecular to Clinical Radiation Biology of Glioblastoma
Perspective of the Large Databases and Ontologic Models of Creation of Preclinical and Clinical Results
Concluding Remarks and Perspectives for Future Research