Nature 2016 №7629 November 17 Volume 539

Nature Published Group. — 289 p. — ISSN: 0028-0836.Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.The Hostile Ocean That Slowed Climate Change
Review
The effects of Δ 9 –tetrahydrocannabinol on the dopamine system
Research. Articles
Forward-genetics analysis of sleep in randomly mutagenized mice
CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells
LKB1 loss links serine metabolism to DNA methylation and tumorigenesis
Thermophilic archaea activate butane via alkyl-coenzyme M formation
Research. Letters
Tidal evolution of the Moon from a high-obliquity, high-angular-momentum Earth
Nanoscale thermal imaging of dissipation in quantum systems
Intrinsically stretchable and healable semiconducting polymer for organic transistors
Kalman Filter for Stripe Non-uniformity Correction in Infrared Focal Plane Arrays
Implications for metal and volatile cycles from the pH of subduction zone fluids
Variability in plant nutrients reduces insect herbivore performance
Neuromodulators signal through astrocytes to alter neural circuit activity and behavior
Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development
PI3Kγ is a molecular switch that controls immune suppression
Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells
Alternative modes of client binding enable functional plasticity of Hsp70
Local regulation of gene expression by lncRNA promoters, transcription and splicing