Jurga S., Erdmann V.A., Barciszewski J. (Eds.) Modified Nucleic Acids in Biology and Medicine

Springer, 2016. — 453 p. — ISBN10: 3319341731.This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties.
The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression.
Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levels of the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have also been found to contain modified nucleosides.
This book is a valuable resource, not only for graduate students but also researchers in the fields of molecular medicine and molecular biology.Transfer RNA Modifications: From Biological Functions to Biomedical Applications
Regulated tRNA Cleavage in Biology and Medicine: Roles of tRNA Modifications
Sulfur Modifications in tRNA: Function and Implications for Human Disease
Regulation of Protein Synthesis via the Network Between Modified Nucleotides in tRNA and tRNA Modification Enzymes in Thermus thermophilus, a Thermophilic Eubacterium
Post-Transcriptional Modifications of RNA: Impact on RNA Function and Human Health
RNA Modification N 6 -Methyladenosine in Post-transcriptional Regulation
8-Hydroxyguanine, an Oxidative DNA and RNA Modification
Methods for Determination of 2 0 -O-Me in RNA
Diadenosine Tetraphosphate (Ap 4 A) in Health and Disease
Thinking Small: Circulating microRNAs as Novel Biomarkers for Diagnosis, Prognosis, and Treatment Monitoring in Breast Cancer
Modified Antisense Oligonucleotides and Their Analogs in Therapy of Neuromuscular Diseases
Effect of Depurination on Cellular and Viral RNA
Recognition of RNA Sequence and Structure by Duplex and Triplex Formation: Targeting miRNA and Pre-miRNA
Modifications in Therapeutic Oligonucleotides Improving the Delivery
Interstrand Cross-Linking of Nucleic Acids: From History to Recent and Future Applications
Chemical Synthesis of Lesion-Containing Oligonucleotides for DNA Repair Studies
Single-Molecule Visualization of Biomolecules in the Designed DNA Origami Nanostructures Using High-Speed Atomic Force Microscopy
Polymerase Reactions that Involve Modified Nucleotides