Couillin Isabelle, Pétrilli Virginie, Martinon Fabio (eds.) The Inflammasomes

Springer Basel, 2011. — 237 p. — (Progress in Inflammation Research). — ISBN10: 3034801475, ISBN13: 978-3034801478.Product DescriptionThe inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1 and IL-18. This finding was substantiated by the identification of several mutations in the cias1 gene, encoding the human NLRP3 protein, responsible for several autoinflammatory disorders such as the Muckle Wells syndrome. Since, the interest for this complex has constantly increased and several inflammasome complexes with different specificities have been described. These inflammasomes sense a wide variety of pathogens and danger signals and are key players in the inflammatory response. With the contributions of leading international experts in the field, this book provides an extensive overview of the current knowledge of inflammasome biology and their role in health and disease.Molecular Definition of Inflammasomes
Pyroptosis: A Caspase-1-Dependent Programmed Cell Death and a Barrier to Infection
Activation of the Inflammasome by Bacterial Pathogens
The Role of Inflammasomes in Viral Infection
Inflammasome Activation in Response to Eukaryotic Pathogens
Inflammasome Activation by Pathogenic Crystals and Particles
Inflammasome Activation by Danger Signals
Toll-Like Receptors and Inflammasomes
Inflammasome in the Skin
Cancer, Inflammasomes, and Adjuvanticity
Inflammasome and Lung Pathologies
Mechanisms of NLRP3 Inflammasome Activation in CAPS Patients
Activation and Regulation of the NLRP3 Inflammasome
Treatment of Inflammasome-Related Disorders