An Zhiqiang (ed.) Therapeutic Monoclonal Antibodies From Bench to Clinic

John Wiley & Sons, Inc, 2009. — 912 p.
Print ISBN: 9780470117910, Online ISBN: 9780470485408
DOI: 10.1002/9780470485408Product Information70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies.
First book to address the discovery and development of antibody therapeutics in their entirety.
Most chapters contain experimental data to illustrate the principles described in them.
Authors provide detailed methodologies that readers can take away with them and use in their own laboratories.Antibody Basics
Therapeutic Monoclonal Antibodies: Past, Present, and Future
Antibody Molecular Structure
Glycosylation of Therapeutic IgGs
Antibody Databases and Tools: The IMGT Experience
Antibody Sources
Human Antibodies from Transgenic Mice
Rabbit Hybridoma
Human Antibody Repertoire Libraries
In Vitro Display Technology
Antibody Phage Display
Yeast Surface Display
Ribosomal Display
Bacterial Display of Antibodies
Antibody Selection from Immunoglobulin Libraries Expressed in Mammalian Cells
Antibody Engineering
Antibody Engineering: Humanization, Affinity Maturation, and Selection Techniques
Modulation of Serum Protein Homeostasis and Transcytosis by the Neonatal Fc Receptor
Engineering the Antibody Fc Region for Optimal Effector Function
Physiology and in Vivo Biology
Antibody-Complement Interaction
Bacteria Immunoglobulin-Binding Proteins: Biology and Practical Applications
Immunogenicity Screening Using in Silico Methods: Correlation between T-Cell Epitope Content and Clinical Immunogenicity of Monoclonal Antibodies
Monoclonal Antibody Pharmacokinetics and Pharmacodynamics
Biodistribution and Imaging
Antibodies and the Blood-Brain Barrier
Antibody Characterization
Determination of Equilibrium Dissociation Constants
Molecular and Functional Characterization of Monoclonal Antibodies
Characterization of Heterogeneity in Monoclonal Antibody Products
Antibody Expression
Antibody Expression in Mammalian Cells
Production of Antibodies in Pichia pastoris
Production of Antibody Fab′ Fragments in E. coli
Production of Human Therapeutic Monoclonal Antibodies in Chicken Eggs
Production of Antibodies in Plants
Therapeutic Antibodies
The Formulation and Delivery of Monoclonal Antibodies
Therapeutic Antibodies in Clinical Use and Leading Clinical Candidates
Follow-On Protein Products: What, Where, When, How?
Monomeric Fc Fusion Molecules
Radioimmunotherapy: Current Status and Future Directions
Antibody-Drug Conjugate Therapy