Klingensmith III W.C. The Mathematics and Biology of the Biodistribution of Radiopharmaceuticals - A Clinical Perspective

Springer International Publishing, Switzerland, 2016. – 277 p. – ISBN10: 3319267027.
This book explores the mathematics and biology of the biodistribution of radiopharmaceuticals following their introduction into the body, but does so primarily from a clinical perspective – from the point of view of image interpretation and any associated image-derived quantification. All of the equations included in the book relate directly to the biodistribution of radiopharmaceuticals and are clinically useful, either conceptually or because of their value in quantifying a biological parameter, e.g., renal clearance. In particular, the more complex equations are not meant to be solved but instead are intended to provide a conceptual basis for the analysis of clinical images, especially those that are unusual and/or difficult to interpret. The efficacy of every diagnostic and therapeutic nuclear medicine procedure is critically dependent on the biodistribution of the radiopharmaceutical in question over time. This book will enable the reader to gain a sound understanding of the relevant mathematics and biology, and the clinical orientation ensures that it will be of value in enhancing clinical practice.Topics.Nuclear Medicine.
Medical and Radiation Physics.Introductory Concepts.
General Concepts in Nuclear Medicine.
Quantitative vs. Visual Interpretation of Images.
Mathematics of the Biodistribution of Radiopharmaceuticals.
Overview of Part II: Mathematics of the Biodistribution of Radiopharmaceuticals.
Evaluation of Clearance.
Mean Transit Time: The Central Volume Principle.
Blood Flow: First Circulation Time- Activity Curves.
Regional Transit Times: Convolution Analysis.
Quantitation of Function: Relative Measurements.
Quantitation of Function: Absolute Measurements.
Other Quantitative Techniques.
Quantitative Evaluation in Nuclear Medicine Studies.
Overview of Part III, Quantitative Evaluation in Nuclear Medicine Studies.
Cardiovascular System.
Central Nervous System.
Endocrine System.
Gastrointestinal System.
Genitourinary System.
Infection Imaging.
Pulmonary System.
Skeletal System.
Tumor Imaging.
Appendix A: Nuclear Medicine Studies Covered in This Book.
Appendix B: Radiopharmaceuticals and Their Associated Studies.
Appendix C: Tables of Extraction Mechanisms and Corresponding Studies.
Appendix D: Distribution of Cardiac Output in the Body at Rest.