Hughes C.L., Waters M.D. (Eds.) Translational Toxicology: Defining a New Therapeutic Discipline

Springer International Publishing, Switzerland, 2016. — 384 p. — ISBN10: 3319274473Defines a new field of therapeutic interventions that could protect, mitigate or reverse the adverse effects of earlier exposures
Explores the range of environmental exposures beyond exclusively that of environmental chemicals and highlights the categories of potential therapeutics Future directions for research needs and opportunities
Bringing together a distinguished interdisciplinary team of contributors, this volume provides a comprehensive exploration of translational toxicology — a systematic approach to developing therapeutic interventions that can protect against, mitigate, or reverse the effects of exposures. In particular, the book addresses modes of action and biomarkers, developmental risks of exposures, and potential translational toxicology therapeutics. The result is a compelling application of developmental toxicology in a new therapeutic discipline that is destined to become part of standard medical practice.
Translational Toxicology: Defining a New Therapeutic Discipline is an essential text for regulatory authorities, scientists, and physicians who are concerned with environmental exposures, public health, nutrition, and pharmaceutical research and development. Basic science, epidemiological, and clinical investigators will also find this book a significant resource.The Opportunity to Translate Developmental Toxicology into a Therapeutic Discipline
The Role of Toxicokinetics and Toxicodynamics in Developmental and Translational Toxicology
Toxicant Modes of Action and Biomarkers
Mutational Effects
Ligand-Mediated Toxicology: Characterization and Translational Prospects
Effects of Environmentally Acquired Heavy Metals and Nutrients on the Epigenome and Phenotype
Fetal Imaging and Effects of Exposures on Growth and Function
Developmental Risks of Exposures and Potential Translational Toxicology Therapeutics
Ovarian Toxicity of Environmental Contaminants: 50 Shades of Grey
The “Toxic” Effects of a Perinatal Obesogenic Environment: Maternal Obesity and Impacts on Future Generations
The Role of Environmental Exposures in Preterm Birth
The Impact of Environmental Stressors on DNA Methylation, Neurobehavioral Development,
and Chronic Physical Aggression: Prospects for Early Protective Interventions
Coffee Health Effects from Early Fetal Development Through Childhood and Adolescence
Ethical Considerations in Development of Future Therapies for Women and Children