Thomas S. (Ed.) Vaccine Design. Volume 1: Vaccines for Human Diseases

Springer Science+Business Media, 2016. — 895 p. — (Methods and Protocols 1403) —ISBN: 149393385X.This text provides a practical guide providing step-by-step protocol to design and develop vaccines. Chapters detail protocols for developing novel vaccines against infectious bacteria, viruses, fungi, and parasites for humans and animals. Volume 1: Vaccines for Human Diseases has an introductory section on how vaccines impacted diseases, the immunological mechanism of vaccines, future challenges for vaccinologists, and current trends in vaccinology. The design of human vaccines for viral, bacterial, fungal, parasitic and prion diseases as well as vaccines for drug abuse, allergy, and tumor vaccines are also described in this volume. As a volume in the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Vaccine Design: Methods and Protocols, Volume 1: Vaccines for Human Diseases aims to ensure successful results in the further study of this vital field.Vaccines : Introduction
Clinical Impact of Vaccine Development
Future Challenges for Vaccinologists
Principles of Vaccination
Trends in Vaccinology
Reverse Vaccinology: The Pathway from Genomes and Epitope Predictions to Tailored Recombinant Vaccines
Systems Vaccinology: Applications, Trends, and Perspectives
Proteomic Monitoring of B Cell Immunity
Vaccines for Human Viral Diseases
Development of Rabies Virus-Like Particles for Vaccine Applications: Production, Characterization, and Protection Studies
Analytic Vaccinology: Antibody-Driven Design of a Human Cytomegalovirus Subunit Vaccine
Generation of a Single-Cycle Replicable Rift Valley Fever Vaccine
Application of Droplet Digital PCR to Validate Rift Valley Fever Vaccines
Methods to Evaluate Novel Hepatitis C Virus Vaccines
Designing Efficacious Vesicular Stomatitis Virus-Vectored Vaccines Against Ebola Virus
Assessment of Functional Norovirus Antibody Responses by Blocking Assay in Mice
Development of a SARS Coronavirus Vaccine from Recombinant Spike Protein Plus Delta Inulin Adjuvant
Generation and Characterization of a Chimeric Tick-Borne Encephalitis Virus Attenuated Strain ChinTBEV
1Single-Vector, Single-Injection Recombinant Vesicular Stomatitis Virus Vaccines Against High-Containment Viruses
Reverse Genetics Approaches to Control Arenavirus
Vaccines for Human Bacterial Diseases
DNA Vaccines: A Strategy for Developing Novel Multivalent TB Vaccines
Overcoming Enterotoxigenic Escherichia coli Pathogen Diversity: Translational Molecular Approaches to Inform Vaccine Design
Design and Purification of Subunit Vaccines for Prevention of Clostridium difficile Infection
The Design of a Clostridium difficile Carbohydrate-Based Vaccine
Murine Models of Bacteremia and Surgical Wound Infection for the Evaluation of Staphylococcus aureus Vaccine Candidates
Using MHC Molecules to Define a Chlamydia T Cell Vaccine
An Approach to Identify and Characterize a Subunit Candidate Shigella Vaccine Antigen
Approach to the Discovery, Development, and Evaluation of a Novel Neisseria meningitidis Serogroup B Vaccine
Anti-Lyme Subunit Vaccines: Design and Development of Peptide-Based Vaccine Candidates
Assessment of Live Plague Vaccine Candidates
Highly Effective Soluble and Bacteriophage T4 Nanoparticle Plague Vaccines Against Yersinia pestis
Development of Structure-Based Vaccines for Ehrlichiosis
Vaccines for Human Fungal Diseases
Dendritic Cell-Based Vaccine Against Fungal Infection
Flow Cytometric Analysis of Protective T-Cell Response Against Pulmonary Coccidioides Infection
Vaccines for Human Parasitic Diseases
High-Density Peptide Arrays for Malaria Vaccine Development
Development and Assessment of Transgenic Rodent Parasites for the Preclinical Evaluation of Malaria Vaccines
DNA Integration in Leishmania Genome: An Application for Vaccine Development and Drug Screening
Methods to Evaluate the Preclinical Safety and Immunogenicity of Genetically Modified Live- Attenuated Leishmania Parasite Vaccines
The Use of Microwave-Assisted Solid-Phase Peptide Synthesis and Click Chemistry for the Synthesis of Vaccine Candidates Against Hookworm Infection
Vaccines for Prion Diseases
Methods and Protocols for Developing Prion Vaccines
Vaccines for Substance Abuse and Toxins
Ricin-Holotoxin-Based Vaccines: Induction of Potent Ricin- Neutralizing Antibodies
Synthesis of Hapten-Protein Conjugate Vaccines with Reproducible Hapten Densities
Vaccines for Allergy
Production of Rice Seed-Based Allergy Vaccines
Allergy Vaccines Using a Mycobacterium-Secreted Antigen, Ag85B, and an IL-4 Antagonist
Development of House Dust Mite Vaccine
Development of Tumor Vaccines
Cancer Vaccines: A Brief Overview
Dendritic Cell Vaccines
T-Cell Epitope Discovery for Therapeutic Cancer Vaccines
Peptide-Based Cancer Vaccine Strategies and Clinical Results
Preconditioning Vaccine Sites for mRNA-Transfected Dendritic Cell Therapy and Antitumor Efficacy
Development of Antibody-Based Vaccines Targeting the Tumor Vasculature
Formulation and Stability of Vaccines
Practical Approaches to Forced Degradation Studies of Vaccines