Ottow E., Weinmann H. Nuclear Receptors as Drug Targets

Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2008. – 522 p. –ISBN: 3527318720.Edited by two experts working at the pioneering pharmaceutical company and major global player in hormone-derived drugs, this handbook and reference systematically treats the drug development aspects of all human nuclear receptors, including recently characterized receptors such as PPAR, FXR and LXR. Authors from leading pharmaceutical companies around the world present examples and real-life data from their own work.Nuclear Receptors as Drug Targets: A Historical Perspective of Modern Drug Discovery.
Targeting the Nuclear Receptor–Cofactor Interaction.
Untangling the Estrogen Receptor Web: Tools to Selectively Study Estrogen-Binding Receptors.
Subtype-Selective Estrogens.
Estrogen Receptors as Therapeutic Targets in Breast Cancer.
Progesterone Receptor: Overview of Modern Steroidal Progestins and Developments in the Field of Nonsteroidal Selective Progesterone Receptor Modulators.
Progesterone Receptor Antagonists.
Nonsteroidal Tissue-selective Androgen Receptor Modulators.
Novel Glucocorticoid Receptor Ligands.
1,25-Dihydroxyvitamin D3 and its Dissociated Analogs as Modulators of Vitamin D Receptor Action.
Peroxisome Proliferator-Activated Receptor g Modulation for the Treatment of Type 2 Diabetes.
Retinoids in Clinical Use.
Nuclear Receptors as Targets in Cardiovascular Diseases.
NR4A Subfamily of Receptors and their Modulators.
15 Induction of Drug Metabolism: Role for Nuclear Receptors.
Designing Chemical Libraries Directed to Nuclear Receptors.