Callan J., Raymo F.M. (Eds.) Quantum Dot Sensors: Technology and Commercial Applications

Pan Stanford, 2013. — 230 p. : 18 Color & 70 B/W Illustrations. — ISBN: 978-981-4364-61-4.Consisting of six chapters, written by experts in their field, this book charts the progress made in the use of quantum dots as the signaling component in optical sensors since their discovery in the early 1980s. In particular, it focuses on CdS-, CdSe-, and CdTe-type QDs due to their emission in the visible region of the electromagnetic spectrum. The book begins by detailing the range of methods currently used for the preparation and passivation of core/core–shell quantum dots and follows with a discussion on their electrochemical properties and potential toxicity. The book culminates by focusing on how electron and energy transfer mechanisms can be utilized to generate a range of quantum dot-based probes. This is the first text of its kind dedicated to quantum dot-based sensors and will appeal to those readers who have an interest in working with these versatile nanoparticles.Quantum Dot Synthesis MethodsHigh-Temperature Synthesis in Organic Solvents
Direct Aqueous Syntheses of QDs
Micellar Synthetic Approaches
Solvothermal Approaches
QD Luminescence Improvement
Further Functionalisation and Bioconjugation of QDs
Concluding Remarks and Future Outlook
Biocompatible CdSe–ZnS Core–Shell Quantum Dots
Semiconductor Quantum Dots
CdSe–ZnS Core–Shell Quantum Dots
Ligand Exchange
Ligand Interdigitation
Bioconjugation
CytotoxicityElectrochemical Properties of Semiconductor Quantum DotsBasic Electronic Properties of QDs
Overview of Electrochemical Techniques Employed for the Investigations on QDs
CdSe Nanocrystals
CdTe Nanocrystals
Nanocrystals Functionalized with Electroactive Molecules
Applications of Electroactive Quantum DotsElectron Transfer Quenching for Biosensing with Quantum Dots
Electron Transfer Quenching
Initial Receptor-Based Biosensors
Protease-Based Biosensors Show Multiplexing Ability
Recent Distance-Dependent Biosensors Demonstrate Analyte Modularity
Toward Biological Imaging of Analyte Concentrations
Quantum Dot Probes Based on Energy Transfer MechanismspH, Ion and Small Molecule FRET Sensors
QD-Peptide/Oligonucleotide FRET Sensors
QD–Antibody Conjugates
QD FRET Probes for Enzyme ActivityQuantum Dot Reactive Oxygen Species Generation and Toxicity in Bacteria: Mechanisms and Experimental PitfallsOverviewQuantum Dots Cores, Shells, and Caps
Band Edge Energies and Possible Reactions in Solution
Measuring Reactive Oxygen Species in the Presence of QDs
Pitfalls: Dyes to Use with Caution
Deliberate Toxicity: Photosensitized QDs
Toxicity to Bacteria: Introduction
CdSe Core QDs
CdSe/ZnS and Photosensitization
Discussion