Drug Discovery Today 2015 v.20 №08

London, UK.: Elsevier. — 224 p.Since its launch in 1996, Drug Discovery Today has been at the cutting edge of the science underpinning drug discovery and development. Drug Discovery Today delivers highly current reviews to the readers, not only addressing the rapid scientific developments in drug discovery associated technologies, but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed.The current state of drug discovery and what it might take to improve drug discovery outcomes and approval successes
Mervyn J. TurnerAn analysis of FDA-approved drugs for infl ammation and autoimmune diseases
Michael S. Kinch and Janie MerkelPredicting clinical response in people at ultra-high risk of psychosis: a systematic and quantitative review
Andrea Mechelli, Diana Prata, Charles Kefford and Shitij KapurClinical implications of leukocyte infi ltration at the choroid plexus in (neuro)infl ammatory disorders
Delphine Demeestere, Claude Libert and Roosmarijn E. VandenbrouckeHigh-content analysis for drug delivery and nanoparticle applications
David J. Brayden, Sally-Ann Cryan, Kenneth A. Dawson, Peter J. O’Brien and Jeremy C. SimpsonPotential therapeutic targets and the role of technology in developing novel antileishmanial drugs
Rajalakshmi Rajasekaran and Yi-Ping Phoebe ChenExploring the potential of global protein-protein docking: an overview and critical assessment of current programs for automatic ab initio docking
Sheng-You HuangLead optimization attrition analysis (LOAA): a novel and general methodology for medicinal chemistry
Mark Munson, Harvey Lieberman, Elina Tserlin, Jennifer Rocnik, Jie Ge, Maria Fitzgerald, Vinod Patel and Carlos Garcia-EcheverriaDiscovery of selective phosphatidylinositol 3-kinase inhibitors to treat hematological malignancies
Jingyu Zhu, Tingjun Hou and Xinliang MaoCancer Research UK Centre for Drug Development: translating 21st-century science into the cancer medicines of tomorrow
James W.A. Ritchie and Robert J. WilliamsThe design of pH-sensitive chitosan-based formulations for gastrointestinal delivery
Hongliang Du, Mengrui Liu, Xiaoye Yang and Guangxi ZhaiPropofol as a transformative drug in anesthesia: insights from key early investigators
Brian T. Bateman and Aaron S. KesselheimRefi ning the chemical toolbox to be fi t for educational and practical purpose for drug discovery in the 21st Century
Marco Lolli, Sarah Narramore, Colin W.G. Fishwick and Klaus PorsDrug repositioning and repurposing: terminology and definitions in literature
Joris Langedijk, Aukje K. Mantel-Teeuwisse, Diederick S. Slijkerman and Marie-Hélène D.B. SchutjensDiary