Shai A., Maibach H.J. Wound Healing and Ulcers of the Skin. Diagnosis and Therapy - the Practical Approach

Springer, 2005. — 279 p. — ISBN: 3-540-21275-2.In this book is introduced the dermatologic perspective of wound healing which applies to the diagnosis of cutaneous ulcers, based on history, physical examination, biopsy, and laboratory tests. Authors also present a therapeutic approach to ulcers according to their appearance.
Authors believe that this guidebook will assist physicians in the treatment of chronic wounds, and that it will ultimately serve to reduce the immense suffering of those afflicted.Basic definitions and introduction
Definitions
Three aspects of treatment in wounds and ulcers
Ulcer depth
Comments on current treatments
Natural course of wound repair versus impared healing in chronic skin ulcersOverviewInflammation phase
Tissue formation phase
Tissue remodeling phase
Types of repair
Chronic ulcers and protracted inflammation
Concluding remarks
Milestones in the history of wound healingOverviewThe ancient world
Antiseptic, identification of bacteria and the use of antibiotics
Investigation of wound healing process
The significance of a moist wound environment
Keratinocyte cultures and advanced skin substitutes
Recent development
Future directions in wound healing
Etiology and mechanisms of cutaneous ulcer formation
Overview: Etiologies of cutaneous ulcers
Mechanisms of ulcer formation
Mechanisms of formation of specific types of cutaneous ulcers
Determining etiology: History and physical examination
Diagnostic approach: overview
Incidence by age: common causes of ulcers in adults and children
Typical location of various cutaneous ulcers
The ulcer's appearance and its surroundings
The primary lesions from which the ulcers originates
Infectious ulcers in various geographical areas
Additional points
Addendum: details regarding venous and arterial ulcers
Determining etiology: Biopsy and laboratory investigationOverviewA cutaneous ulcer in which the clinical diagnosis is not established
A non-healing ulcers
Suspected malignancy
An ulceration nodule or plaque
Pyoderma gangrenosum
Ulcer measurement and patient assessmentUlcer/wound measurements
Patient assessment
Summary tables
Dressing materialsOverviewTraditional dressings: non-resorbable gauze-sponge dressings
development of advanced dressing modalities
Features of dressings
Advanced dressing modalities
Other types of dressingsDebridement
Definition of debridement
Appearance of necrotic material on an ulcer's surface
Why should ulcers be debrided
Methods of debridement
Disadvantages of and contraindications to debridement: final commentsAntibiotics, antiseptics, and cutaneous ulcers
Overview: detrimental effects of bacteria on wound healing
Antibiotics and antiseptics: definition and properties
Infected ulcers, clean ulcers, and noan-healing "unclean" ulcers
Systemic antibiotics for cutaneous ulcers
Topical preparations for infected cutaneous ulcers and "unclean" ulcers
Guidelines for the use of topical antibiotics and antiseptic preparations in the management of cutaneous ulcers
Addendum A: collection and identification of pathogenic bacteria
Addendum B: biofilms
Topical antibacterial agentsOverviewOxidizing agents
Iodines
Chlorines
Silver
Other antisepticsSkin graftingSplit-thickness skin graft and full-thickness skin graft
Preparing a cutaneous ulcer for grafting
Forms of autologous graftingSkin substitutes and tissue-engineered skin equivalentsOverview"Non-living" skin substitutes
"Living" skin substitutesHuman skin equivalents: When and how to use
General structure and mechanism af action
Product description
Indications
Instructions for use
Contraindications
Efficacy
Concluding remark
Growth factorsOverviewWhat are growth factors?
Beneficial effects of growth factors on acute wounds and chronic cutaneous ulcers
Recombinant human platelet-derived growth factor: rhPDGF (Becaplermin)
Research studies using recombinant human PDGF
PDGF: indications and contraindications
Mode of using PDGF gel preparation
Topical use of other growth factors
Summary and future research
Drugs, wound healing and cutaneous ulcersOverviewUlceration at the injection site
Direct cutaneous exposure
Systemic drugs that directly induce ulceration
Interference with normal mechanisms of wound healing
Drugs that adversely affect skin quality
Alternative skin preparationsOverviewHerbal and traditional home remedies
HoneyAdditional topical preparationsOverviewVitamins and trace elements
Scarlet red
Hialuronic acid derivatives
Biafine
Nutrition and cutaneous ulcersOverviewMalnutrition
Vitamins
Trace elementsTherapeutic approach to cutaneous ulcers according to appearanceOverviewSecreting "Yellow" ulcers
Dry "Black" ulcers
"Sloughy" ulcers
Clean "Red" ulcers
"Unresponsive" ulcers
"Mixed" ulcers
Additional comments
Treating hypergranulation tissue
Addendum: dressing that apply topical negative pressure
Appendix: Guidelines for patients and medical staff
General patient guidelines for treatment of ulcers or wounds at home
Patient guidelines for the management of skin ulcers caused by venous insuffiency
Patient guidelines for the management of skin ulcers caused by diabetes or peripheral arterial disease
Treatment of edema
Guidelines for nurses: outpatient management of cutaneous ulcers
Subject index
List of products