Goins B.A., Phillips W.T. (eds.) Nanoimaging

Pan Stanford, 2011. — 302 p.The last decade has seen significant advances in the fabrication of new nanostructures, including nanoparticles. In parallel, considerable progress in the design of new imaging equipment and development of contrast agents has occurred. The translation of these nanostructures into clinical nanomedicine and diagnostic imaging applications is emerging rapidly with a burgeoning growth of different nanoparticles being tested.
This volume of the Pan Stanford Series on Biomedical Nanotechnology, edited by Vladimir Torchilin and Mansoor Amiji, is devoted especially to reviewing the current status of the use of nanoparticles in in vivo imaging applications. The book begins with a review of nanoparticles for oncologic imaging, a major clinical application (Chapter 1). Chapters 2–5 focus on in vivo imaging of iron oxide particles and liposomes, some of the first nanoparticles to be used as diagnostic imaging agents clinically. Chapters 6–12 highlight the use of new nanoparticles that are currently at the preclinical stage of testing, such as quantum dots, dendrimers, polymer-based nanoparticles, gold nanoshells, carbon nanotubes, and metal nanorods. Finally, although not technically nanoparticles, no comprehenisive review on imaging contrast agents would be complete without the inclusion of microbubbles for ultrasound contrast (Chapter 13). This volume has attempted to represent the major clinical imaging modalities of magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography (PET), single photon emission computed tomography (SPECT), and ultrasound as well as optical methods.
The overall thrust of this volume highlights the specific advantages of nanoparticles for drug delivery and imaging applications. Nanoparticles are able to target the delivery of therapeutic and imaging agents and retain these agents at local sites using different approaches not possible with small (free) molecules. In conjunction, noninvasive imaging can monitor the biodistribution of the nanoparticles as drug carriers and contrast agents and more importantly determine how successfully the intended target was reached. Moreover, the versatile nature of nanoparticles allows for their use as multimodality imaging agents as well as theranostics for carrying both diagnostic and therapeutic agents. Thus, readers should find that the principles learned from the in vivo imaging of one type of nanoparticle are useful for investigations of other kinds of nanoparticles.Combined Contrast and Therapeutic Nanocarriers for Oncologic MRI
Nano-Size Superparamagnetic Magnetic Resonance Contrast Agents
In vivo Imaging of Immunotherapy Using Nanoparticles
Radiolabeled Liposomes as Theranostic Agents
Antibody-Targeted Liposomes and Micelles for Imaging Applications
Quantum Dot-Based Multimodality Imaging Agents
Multimodal Imaging of Dendrimers
Multifunctional, Multimodality Cancer Imaging with Water-Soluble Synthetic Polymer Nanoparticles
PLGA-Based Optical Imaging in Breast Cancer
Radiolabeled Gold Nanoshells for in vivo Imaging: Example of Methodology for Initial Evaluation of Biodistribution of a Novel Nanoparticle
Combined Photoacoustic and Ultrasound Imaging of Metal Nanoparticles in vivo
Imaging Carbon Nanotubes in vivo: A Vignette of Imaging Modalities at the Nanoscale
Ultrasound Contrast Microbubbles: In vivo Imaging and Potential Therapeutic Applications