Clayden J. (ed.) Tetrahedron Organic Chemistry Series. Volume 23. Organolithiums: Selectivity for Synthesis

Elsevier Ltd., 2002. — 383 p. — ISBN: 978-0-08-043262-5The importance of organolithium chemistry to organic synthesis is undisputed: functionalisation by lithiation and electrophilic quench is among the most fundamental of synthetic transformations. Chemists will often turn to organolithium methods because of their simplicity, and with standard laboratory equipment and careful technique organolithiums are straightforward reagents to handle. Not for some years, however, have the themes of organolithium chemistry been brought together in a single book. My aim has been to do this, reviewing established procedures such as directed metallation and reductive lithiation and summarising recent discoveries in developing areas such as the use of (-)-sparteine as a ligand. I have aimed to provide clear mechanistic explanations for the control of selectivity which organolithiums (often uniquely) allow, and I have aimed to provide a valuable resource for all chemists carrying out synthesis, whether graduate students or professional chemists in industry.Regioselective Synthesis of Organolithiums by Deprotonation
Regioselective Synthesis of Organolithiums by X-Li Exchange
Regioselective Synthesis of Organolithiums by C–X Reduction
Stereoselective and Stereospecific Synthesis of Organolithiums
Stereoselective and Stereospecific Substitution Reactions of Organolithiums
Regio- and Stereoselective Addition Reactions of Organolithiums
Organolithium Rearrangements
Organolithiums in Synthesis