Fischer J., Ganellin C.R. (Eds.) Analogue-based Drug Discovery

Weinheim: Wiley-VCH Verlag GmbH & Co. KGaA. – 2006. – 607 p. This book focuses on both structural and pharmacological analogues – that is, those analogues which have similar chemical and biological properties – although some examples are also included where the analogue is derived purely on a similar chemical or a similar biological basis (but not both). Within the book, it is shown how analogues play an important role in medicinal chemistry and, more importantly, how they optimize drug therapies. Hence, it was for this reason that we sought to select diverse fields of drug research and medicinal chemistry. The aim of the book was not to provide a comprehensive review, but rather to describe selected analogue classes in a more detailed manner. In support of this aim, we should point out that nine of the authors have played key roles as coinventors in the discovery of some of the very important drugs detailed in the book. This book should serve as a useful reference for experts in medicinal chemistry and also for students of this field. Moreover, it will also be of interest to a wide range of scientists, including organic chemists, biochemists, pharmacologists and clinicians, who are interested in drug research.General Aspects of Analogue-Based Drug Discovery.
Analogues as a Means of Discovering New Drugs.
Drug Likeness and Analogue-Based Drug Discovery.
Privileged Structures and Analogue-Based Drug Discovery.
Selected Examples of Analogue-Based Drug Discoveries.
Development of Anti-Ulcer H2-Receptor Histamine Antagonists.
Esomeprazole in the Framework of Proton-Pump Inhibitor Development.
The Development of a New Proton-Pump Inhibitor: The Case History of Pantoprazole.
Optimizing the Clinical Pharmacologic Properties of the HMG-CoA.
Optimizing Antihypertensive Therapy by Angiotensin Receptor Blockers.
Optimizing Antihypertensive Therapy by Angiotensin-C onverting Enzyme Inhibitors.
Case Study of Lacidipine in the Research of New Calcium Antagonists.
Selective Beta-Adrenergic Receptor-Blocking Agents.
Case Stady Esmolol Stat.
Development of Organic Nitrates for Coronary Heart Disease.
Development of Opioid Receptor Ligands.
Stigmines.
Structural Analogues of Clozapine.
Quinolone Antibiotics: The Development of Moxifloxacin.
Cisplatin and its Analogues for Cancer Chemotherapy.
The History of Drospirenone.
Histamine H1 Blockers: From Relative Failures to Blockbusters Within Series of Analogues.
Corticosteroids: From Natural Products to Useful Analogues.
Table of Selected Analogue Classes.