Hanessian S. (ed.) Natural Products in Medicinal Chemistry

Wiley-VCH, 2014. — 654 p. — ePDF ISBN: 978-3-527-67655-2The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters.
Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new drugs with improved properties over their progenitors.
The examples are chosen so as to represent a wide range of natural products with therapeutic relevance among others, as anticancer agents, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics.Personal Foreword
Natural Products as Sources of Potential Drugs and Systematic Compound Collections
Natural Products as Drugs and Leads to Drugs: An Introduction and Perspective as of the End of 2012
Natural Product-Derived and Natural Product-Inspired Compound Collections
From Marketed Drugs to Designed Analogs and Clinical Candidates
Chemistry and Biology of Epothilones
Taxol, Taxoids, and Related Taxanes
Camptothecin and Analogs
A Short History of the Discovery and Development of Naltrexone and Other Morphine Derivatives
Lincosamide Antibacterials
Platensimycin and Platencin
From Natural Product to New Diabetes Therapy: Phlorizin and the Discovery of SGLT2 Inhibitor Clinical Candidates
Aeruginosins as Thrombin Inhibitors
Natural Products as an Incentive for Enabling Technologies
Macrolides and Antifungals via Biotransformation
Unnatural Nucleoside Analogs for Antisense Therapy
Hybrid Natural Products
Natural Products as Pharmacological Tools
Rethinking the Role of Natural Products: Function-Oriented Synthesis, Bryostatin, and Bryologs
Cyclopamine and Congeners
Nature: The Provider, the Enticer, and the Healer
Hybrids, Congeners, Mimics, and Constrained Variants Spanning 30 Years of Natural Products Chemistry: A Personal Retrospective