Staag Charlotte, Rothman Douglas. Magnetic Resonance Spectroscopy: Tools for Neuroscience Research and Emerging Clinical Applications

Academic Press, 2013. — 398 p.Magnetic Resonance Spectroscopy: Tools for Neuroscience Research and Emerging Clinical Applications is the first comprehensive book for non-physicists that addresses the emerging and exciting technique of magnetic resonance spectroscopy. Divided into three sections, this book provides coverage of the key areas of concern for researchers. The first, on how MRS is acquired, provides a comprehensive overview of the techniques, analysis, and pitfalls encountered in MRS; the second, on what can be seen by MRS, provides essential background physiology and biochemistry on the major metabolites studied; the final sections, on why MRS is used, constitutes a detailed guide to the major clinical and scientific uses of MRS, the current state of teh art, and recent innovations.Section 1: Technical Aspects - How MRS Is Acquired
Basis of Magnetic Resonance
Localized Single-Voxel Magnetic Resonance Spectroscopy, Water Suppression, and Novel Approaches for Ultrashort Echo-Time Measurements
Technical considerations for Multivoxel Approaches and Magnetic Resonance Spectroscopic Imaging
Spectral Editing and 2D NMR
Spectral Quantification and Pitfalls in Interpreting Magnetic Resonance Spectroscopic Data: What to Look Out ForSection 2: Biochemistry - What Underlies the Signal?
N-Acetylaspartate and N-Acetylaspartylglutamate in Central Nervous System Health and Disease
The Biochemistry of Creatine
The Biochemistry of Choline
Glutamate
Other Significant Metabolites: Myo-Inositol, GABA, Glutamine, and LactateSection 3: Applications of Proton-MRS
Usefulness of Proton Magnetic Resonance Spectroscopy in the Clinical Management of Brain Tumors
Multiple Sclerosis and Inflammatory Diseases
Epilepsy
Stroke and Cerebral Ischaemia
Use of MRS in Inborn Errors of Metabolism: Canavan’s Disease and MRS in Differential Diagnosis
MRS of Psychiatric Disorders
Preclinical and Clinical Applications of 1H-MRS in the Spinal Cord
Interindividual Differences in Behavior and Plasticity
MRS in Development and Across the Lifespan
Hormonal Influences on Magnetic Resonance Spectroscopy Measures
Magnetic Resonance Spectroscopy in Neuroenergetics and NeurotransmissionSection 4: Applications of Non-Proton MRS
Quantitative Metabolic Magnetic Resonance Imaging of Sodium, Oxygen, Phosphorus, and Potassium in the Human Brain: A Rationale for Bioscales in Clinical Applications
Carbon (13C) MRS
Hyperpolarized Magnetic Resonance Imaging and Spectroscopy of the Brain