Picart C., Caruso F., Voegel J.-C. (ed.) Layer-by-Layer Films for Biomedical Applications

Wiley-VCH Verlag GmbH & Co., 2015. — 592 p.The layer-by-layer (LbL) deposition technique is a versatile approach for preparing nanoscale multimaterial films: the fabrication of multicomposite films by the LbL procedure allows the combination of literally hundreds of different materials with nanometer thickness in a single device to obtain novel or superior performance. In the last 15 years the LbL technique has seen considerable developments and has now reached a point where it is beginning to find applications in bioengineering and biomedical engineering.
The book gives a thorough overview of applications of the LbL technique in the context of bioengineering and biomedical engineering where the last years have witnessed tremendous progress. The first part familiarizes the reader with the specifics of cell-film interactions that need to be taken into account for successful application of the LbL method in biological environments. The second part focuses on LbL-derived small drug delivery systems and antibacterial agents, and the third part covers nano- and microcapsules as drug carriers and biosensors. The fourth and last part focuses on larger-scale biomedical applications of the LbL method such as engineered tissues and implant coatings.Part I. Control of Cell/Film Interactions:
Controlling cell adhesion using pH-modified polyelectrolyte multilayer films;
The interplay of surface and bulk properties of polyelectrolyte multilayers in determining cell adhesion;
Photocrosslinked polyelectrolyte films of controlled stiffness to direct cell behavior;
Nanofilm biomaterials: dual control of mechanical and bioactive properties;
Bioactive and spatially organized LbL films;
Controlling stem cell adhesion, proliferation, and differentiation with layer-by-layer films;
Part II. Delivery of Small Drugs, DNA and siRNA:
Engineering layer-by-layer thin films for multiscale and multidrug delivery applications;
Polyelectrolyte multilayer coatings for the release and transfer of plasmid DNA;
LbL-based gene delivery: challenges and promises;
Subcompartmentalized surface-adhering polymer thin films toward drug delivery applications;
Part III. Nano- and Microcapsules as Drug Carriers:
Multilayer capsules for in vivo biomedical applications;
Light-addressable microcapsules;
Nanoparticle functionalized surfaces;
Layer-by-layer microcapsules based on functional polysaccharides;
Nanoengineered polymer capsules: moving into the biological realm;
Biocompatible and biogenic microcapsules;
Three-dimensional multilayered devices for biomedical applications;
Part IV. Engineered Tissues and Coatings of Implants:
Polyelectrolyte multilayer film - a smart polymer for vascular tissue engineering;
Polyelectrolyte multilayers as robust coating for cardiovascular biomaterials;
LbL nanofilms through biological recognition for 3D tissue engineering;
Matrix-bound presentation of bone morphogenetic protein 2 by multilayer films: fundamental studies and applications to orthopedics;
Polyelectrolyte multilayers for applications in hepatic tissue engineering;
Polyelectrolyte multilayer film for the regulation of stem cells in orthopedic field;
Axonal regeneration and myelination: applicability of the layer-by-layer technology;