Science 2015 Volume 347 №6217 January 2

Founded in 1880 on $10,000 of seed money from the American inventor Thomas Edison, Science has grown to become the world's leading outlet for scientific news, commentary, and cutting-edge research, with the largest paid circulation of any peer-reviewed general-science journal. Through its print and online incarnations, Science reaches an estimated worldwide readership of more than one million. In content, too, the journal is truly international in scope; some 35 to 40 percent of the corresponding authors on its papers are based outside the United States. Its articles consistently rank among world's most cited research.Roundup of the week’s news.E. Pennisi. Inching Toward the 3D Genome.
Maps of DNA’s loops and folds advance — but may disagree.J. You. Geoscientists Aim to Magnify Specialized Web Searching.
National Science Foundation project, GeoLink, could become search hub for the geoscience community.J. Couzin-Frankel. The Bad Luck of Cancer.
Analysis suggests most cases can’t be prevented.
Report p.78.K. Servick. Targets of Misconduct Probe Launch a Legal Counterattack
Heart researchers claim inquiry damaged their careers and derailed the sale of stem cell company.R. Stone. Exodus from the East.
Thousands of scientists - along with entire universities - have fled war-torn eastern Ukraine. Others have staked their futures on the breakaway republics.R. Stone. Ukraine mourns a lost science jewel.M. Leslie. Inflammation’s Stop Signals.
Inflammation doesn’t just peter out. The body actively shuts it down, using signals that researchers hope to transform into therapies.Nextgen's Course Catalog.J. F. Alcorn and J. K. Kolls. Killer Fat.
Adipocytes in the skin release an antimicrobial factor to fight staphylococcus infection.
Report p.67A. G. Clark and P. W. Messer. Conundrum of Jumbled Mosquito Genomes.
Multiple Anophelesmosquito genome sequences reveal extreme levels of mixing.
Research Articles pp.42 & 43C. R. Landis. Construction and Deconstruction of Aldehydes by Transfer Hydroformylation.
A soluble rhodium catalyst converts alkenes to aldehydes without the need for toxic or explosive gas-phase reactants.
Report p.56D. W. Holden. Persisters Unmasked.
Intracellular toxins cause bacterial growth arrest and antibiotic tolerance.S. Han and A. Brunet. Lysosomal Lipid Lengthens Life Span.
A fatty acid moves from the lysosome to the nucleus, altering gene expression and extending longevity in the worm.
Report p.83J. Reich. Rebooting MOOC Research.
Improve assessment, data sharing, and experimental design.
PodcastJ. Donath, reviewed by J. Golbeck. The Social Machine.P. Hatfield and T. Harper, curators; reviewed by J. Fahrenkamp-Uppenbrink. Lines in the Ice.From 'Science' and other journals.2D Materials.
F. Bonaccorso et al. Graphene, related two-dimensional crystals, and hybrid systems for energy conversion and storage
Review Summary; for full text: dx.doi.org/10.1126/science.1246501Mosquito Genomics.
M. C. Fontaine et al. Extensive introgression in a malaria vector species complex revealed by phylogenomics.
Research Article Summary; for full text: dx.doi.org/10.1126/science.1258524D. E. Neafsey et al. Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes.
Research Article Summary; for full text: dx.doi.org/10.1126/science.1258522
Perspective p.27V. Zickermann et al. Structural Biology.
Mechanistic insight from the crystal structure of mitochondrial complex I.A. Buitrago Santanilla et al. Organic Chemistry.
Nanomole-scale high-throughput chemistry for the synthesis of complex molecules.D. Kienzler et al. Quantum Optics.
Quantum harmonic oscillator state synthesis by reservoir engineering.S. K. Murphy et al. Organic Chemistry.
Rh-catalyzed C–C bond cleavage by transfer hydroformylation.
Perspective p.29T. Yang et al. Reaction Dynamics.
Extremely short-lived reaction resonances in Cl + HD (v= 1)→ DCl + H due to chemical bond softening.S. Borgeaud et al. Bacterial Evolution.
The type VI secretion system of Vibrio choleraefosters horizontal gene transfer.L. Zhang et al. Innate Immunity
Dermal adipocytes protect against invasive Staphylococcus aureusskin infection.
Perspective p.26Y. Liu et al. Virus Structure.
Structure and inhibition of EV-D68, a virus that causes respiratory illness in children.P. S. Shen et al. Protein Syntesis.
Rqc2p and 60Sribosomal subunits mediate mRNA-independent elongation of nascent chains.C. Tomasetti and B. Vogelstein. Cancer Etiology.
Variation in cancer risk among tissues can be explained by the number of stem cell divisions.
News Story p.12J. P. Dumanski et al. Mutagenesis.
Smoking is associated with mosaic loss of chromosome Y.A. Folick et al. Aging.
Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans.
Perspective p.32Marcia McNutt. Editorial.
Data, eternal.Mary Poffenroth. Working Life.
My liberation through science.On the CoverColored scanning electron micrograph of the mouthparts of a female Anopheles gambiaemosquito.
Sheathed in a scaly lower lip ending in two hairy lobes (blue) are a pair of saw-toothed stylets (green) used to cut into the skin.
Because only female Anophelesblood feed, only females transmit malaria — a disease that claims the lives of more than half a million children each year. See pages 27, 42, and 43.
Image: Science Photo Library