Conn P.M., Means A.R. Principles of Molecular Regulation

Humana Press, 2000. — 489 p.
P. Michael Conn and Anthony Means have successfully assembled a panel of leading investigators to provide an integrated review of the key areas - membrane receptor-initiated cell signaling and nuclear-receptor initiated gene regulation. Chosen for the excellence of their research, these distinguished authors illuminate the molecular machinery underlying the regulatory processes of cells. In addition to their comprehensive review of the signaling mechanisms involving cell surface receptors, nuclear receptors, and ion channels, they detail the roles of calcium, lipids, cyclic AMP, protein kinases, and protein phosphatases. Capturing the excitement now present at this vibrant union of molecular biology, cell biology, and endocrinology, Principles of Molecular Regulation constitutes a major new resource for understanding the many and complex elements of biological regulation. Its up-to-date critical synthesis is certain to prove of high value to all basic and clinical investigators working with these processes today.Signaling Mechanisms Initiated by Cell Surface Receptors
G Protein-Coupled Receptors and G Proteins
G Proteins Large and Small Guanine Nucleotide Binding Proteins: Cellular Comunication Networks
The Insulin Receptor Kinase: Regulation and Therapeutic Significance
Growth Hormone Action: Signaling via a JAK/STAT-Coupled Receptor
Regulation of Drosophila Visual Transduction Through a Supramolecular Signaling Complex
Dictyostelium: A Model Experimental System for Elucidating the Pathways and Mechanisms Controlling Chemotaxis
gp 130-Related Cytokines
Signaling Mechanisms Mediated by Ion Channels, Calcium, and Lipids
Ion Channels
Calcium Ions as Intracellular Messengers: Pathways and Actions
Calcium and Calmodulin-Mediated Regulatory Mechanisms
Protein Kinase C
Nitric Oxide
Phospholipases
Cyclic AMP, Protein Kinases and Protein Phosphatases
Adenylyl Cyclases
Cyclic Nucleotide Phosphodiesterases
Cyclic Nucleotide-Dependent Protein Kinases
Protein Serine/Threonine Kinases
Protein Serine/Threonine Phosphatases
Protein Tyrosine Phosphatases
Signaling Mechanisms Initiated by Nuclear Receptors
The Mechanisms of Action of Steroid Hormone Receptors
Orphan Nuclear Receptors
Coactivators and Corepressors
CREB Binding Protein-Coactivator Complexes
Molecular Regulation of Cell Proliferation and Death
Cell Cycle Checkpoints
Molecular Regulation of Apoptosis
T Cells and Immunosuppression
Rational Drug Discovery
Rational Drug Discovery and the Impact of New, Advanced Technologies