Pitot H.C., Loeb D.D. Fundamentals of Oncology

New York: Marcel Dekker. – 2002. – 1010 p. This text is not meant to be a popular account of the cancer problem. More than two decades ago, the Department of Oncology, which comprises the McArdle Laboratory for Cancer Research of the University of Wisconsin at Madison, initiated a graduate course in oncology. This course consisted of a series of lectures covering a variety of aspects of experimental oncology including chemical and biological carcinogenesis, host-tumor relationships, the natural history of cancer, and the biochemistry of cancer. In addition, within a few years of its inception, several lectures were given on the diagnosis and therapy of cancer in the human patient. The course was and always has been oriented primarily toward the graduate student in oncology rather than specifically for the medical student or postgraduate physician. In part as a result of the increased interest in cancer research by both graduate and undergraduate students and as part of the mechanism of self-evaluation of teaching programs, several years ago the McArdle Laboratory expanded its original course into three separate courses in experimental oncology. The first course in this series is open to all students and fellows at the University of Wisconsin, and the notes given to the students comprise the basis for this short text on the fundamentals of oncology. It has been some 15 years since the last edition of this text was published. The original purpose of the book was to replace notes in a course, Introduction to Experimental Oncology, which has been given in the Department of Oncology at the University of Wisconsin–Madison for more than 25 years. The course has evolved from being primarily directed towards graduate students to one that includes more than 80% undergraduates, usually juniors and seniors in various sciences. The course has always been offered for two credits, but with the enormous increase in information in the field of oncology, it will likely be increased to three credits. In this revision, four new chapters have been added and the other chapters significantly expanded. The genetics of neoplasia is now covered in two chapters, as is the stage of progression. Discussion of carcinogenesis in humans has also been expanded to two full chapters in addition to the chapter on the evaluation of risk of carcinogenic environmental agents. Finally, another chapter has been added in the area of host–tumor relationships, covering endocrine and stromal responses.Cancer: Yesterday and Today
The Language of Oncology
The Etiology of Cancer: Chemical and Physical Agents
The Etiology of Cancer as an Infectious Disease
The Etiology of Cancer: Germline Genetic Factors
The Etiology of Cancer: Somatic Cell Genetics
The Natural History of Neoplastic Development: Initiation and Promotion
The Natural History of Neoplastic Development: Host Effects During Carcinogenesis
The Natural History of Neoplastic Development: Progression
Consequences of the Stage of Progression
Environmental Factors in the Etiology of Human Cancer — Chemical Agents and Processes
Environmental Factors in the Etiology of Human Cancer — Physical and Biological Agents
Evaluation of Toxic and Carcinogenic Environmental Agents: Scientific and Societal Considerations and Their Role in Cancer Prevention
The Natural History of the Development of Neoplasia in Cultured Cells and Tissues
The Cellular and Molecular Biology of Neoplasia in Vivo
Cellular and Molecular Biology of Neoplastic Transformation in Vitro
The Host–Tumor Relationship — Nutritional Factors and Biomarkers
The Host–Tumor Relationship — Endocrine Factors and Stromal Reaction
Immunobiology of the Host–Tumor Relationship
Some Basic and Applied Principles of Cancer Chemotherapy
Epilogue: Cancer: Tomorrow and the Future