Sambamurthy K., Kar A. Pharmaceutical Biotechnology

New Delhi: New Age International (P). - 2006. — 502 p. Pharmaceutical Biotechnology, based entirely on modern biotechnological techniques, as to date encompass a wider range of altogether newer medicinal compounds, e.g., antibiotics, vaccines, and monclonal antibodies (MABs) that may now be produced commercially using well-defined, optimized, and improved fermentative methodologies. In fact, genetic engineering has brought in a sea change by virtue of the directed construction of microorganisms resulting in a plethora of newer life-saving drugs. The present textbook on 'Pharmaceutical Biotechnology' is strictly developed, structured, expanded, and expatiated along the guidelines provided by AICTE syllabus for B. Pharmacy-2000. It essentially consists offive main chapters, namely : Immunology and Immunological Preparations ; Genetic Recombination ; Antibiotics ; Microbial Transformations ; and Enzyme Immobilization. In addition to this, there are five auxilliary chapters, namely : Advent of Biotechnology ; Biosensor Technology ; Bioinformatics and Data Mining ; Regulatory Issues in Biotechnology ; and Safety in Biotechnology, which have been duly included so as to stimulate the students' interest and expand their knowledge.Immunology and Immunological PreparationsPrinciples
Antigens and Haptens
Immune Systems
Antigen Antibodies Reactions and their Applications
Hypersensitivity Reaction
Vaccines: Preparation, Standardization and Storage
Genetic RecombinationTransformation
Conjugation
Transduction
Protoplast Fusion
Gene Cloning
Development of Hybridoma for Monoclonal Antibodies (MABs)
Drugs Produced by Biotechnology
Antibiotics
Historical Development of Antibiotics
Antimicrobial Spectrum and Methods Used for their Standardization
Screening or Soil for Organisms Producing Antibiotics
Fermentors [or Bioreactors]
Mutants
Design of Fermentation Processes
Production of Antibiotics (Isolation of Fermentation Products)
Future Prospects
Microbial Transformations
Types of Reactions Mediated by Microorganisms
Design of Biotransformation Processes
Selection of Organisms.
Biotransformation Process and Its Improvements with Special
Reference to Steroids
Enzyme Immobilization
Methods of Immobilization
Factors Affecting Enzyme Kinetics
Profile of Some Important Enzymes
Immobilization of Bacteria and Plant Cells
Advances in Biotechnology
Biosensor Technology
Types of Electrodes Used in Biosensors
Biosensor Variants
Biochips (or The Biological Computer)
Bioinformatics and Data Mining
Sequential Growth in Bioinformatics
Web Services
Alignment Tools
Data Mining
Selected Organization vis-a-vis Interest in Bioinformatics
Wonders of Bioinformatics and Data Mining
Bioinformatics Information Centres in India
Regulatory Issues in Biotechnology
Intellectual Property Right (IPR) and Protection (IPP)
Safety in Biotechnology
Biosafety
Pathogenic Microorganisms and Fungi