Vogel H.G. (Ed.) Drug Discovery and Evaluation: Pharmacological Assays

3rd Edition. - Springer, 2008. - 2118 p. - Many young pharmacologists have only limited training in traditional methodologies, as these still-relevant methods are simply not available in today’s electronic databases. Drug Discovery and Evaluation: Pharmacological Assays corrects this problem by comprehensively covering the pharmacological methods that have been utilized successfully for more than a hundred years as well as the latest technologies. Thoroughly revised and expanded to two volumes, it offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Every chapter has been updated, and numerous assays have been added. Each of the more than 1,000 assays comprises a detailed protocol outlining purpose and rationale, and a critical assessment of the results and their pharmacological and clinical relevance.Introduction Strategies in Drug Discovery and Evaluation
Cardiovascular Activity
Pharmacological Assays in Thrombosis and Haemostasis
Activity on Urinary Tract
Respiratory Activity
Psychotropic and Neurotropic Activity
Drug Effects on Learning and Memory
Effects On Peripheral Nerve Function
Analgesic, Anti-inflammatory, and Anti-pyretic Activity
Antiarthrotic and Immunomodulatory Activity
Activity on the Gastrointestinal Tract
Antidiabetic Activity
Anti-obesity Activity
Anti-Atherosclerotic Activity
Endocrinology
Ophthalmologic Activity
Pharmacological Models in Dermatology
Guidelines for the Care and Use of Laboratory Animals